PROPYLTHIOURACIL IN THYROTOXICOSIS
- 19 April 1947
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 133 (16) , 1190-1192
- https://doi.org/10.1001/jama.1947.02880160016003
Abstract
Propylthiouracil has been recommended by Astwood and VanderLaan1 as an effective substitute for thiouracil. Its antithyroid action in rats is approximately ten times that of thiouracil, and while it is more toxic than the latter on a weight basis, it is less toxic in quantities having a comparable therapeutic effect. Clinical observations oh the first 52 patients treated1 point out that with few exceptions, 50 to 75 mg. propylthiouracil a day is an adequate initial dose, while 25 to 50 mg. a day is sufficient for maintenance. The antithyroid action is less intense than that of thiouracil; myxedema and thyroid enlargement have occurred only infrequently, and side reactions, not at all. From this study it appears that the new drug has approximately five times the activity of thiouracil, with few if any of the obstacles presented by the latter. Fifty-four patients have been treated with propylthiouracil by meKeywords
This publication has 1 reference indexed in Scilit:
- Thiouracil Derivatives of Greater Activity for the Treatment of Hyperthyroidism1Journal of Clinical Endocrinology & Metabolism, 1945