Failure of Prolonged Sulfonylurea Administration to Enhance Insulogenic Response to Glycemic Stimulus
- 1 July 1965
- journal article
- research article
- Published by American Diabetes Association in Diabetes
- Vol. 14 (7) , 392-395
- https://doi.org/10.2337/diab.14.7.392
Abstract
The effect of chronic administration of sulfonylurea compounds on the insulogenic responsiveness of beta cells was studied in normal dogs who received hypoglycemia-maintaining dosages of tolbutamlde daily for several weeks. Insulin concentration in pancreatlcoduodenal venous blood was measured during infusion of glucose at a rate causing physiologic increase in arterial glucose concentration. Neither fasting plasma insulin level nor its enhancement during progressive hyper-glycemla was significantly greater in tolbutamide-treated animals than in the control group. The data indicate that prolonged exposure of non-diabetic canine beta cells to effective concentrations of sulfonylurea does not increase their insulin-secretory responsiveness to glycemic stimulus. Whether these agents impinge similarly or differently upon diabetic human islets awaits elucidation. It was parenthetically observed that dogs treated with tolbutamide for several weeks required more than twice the usual amount of Nembutal (pentobarbital) to maintain surgical anesthesia.Keywords
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