Steric origin of isotope effects in nuclear magnetic resonance shifts induced by lanthanide shift reagents; effect of deuteriation of methyl substituted pyridines
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 984-985
- https://doi.org/10.1039/c39760000984
Abstract
Deuteriation of all the methyl groups, or the 2- and 6-methyl groups, in 2,4,6-trimethylpyridine causes a large (ca. 6%) isotope effect on the lanthanide-induced shift for the 3- and 5-hydrogen atoms, whereas the effect of deuteriation of the 4-methyl group is not detectable (<0·2%); a steric origin is proposed for the secondary isotope effect in lanthanide-induced shifts.Keywords
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