Case of a mentally retarded child with non‐24 hour sleep–wake syndrome caused by deficiency of melatonin secretion
Open Access
- 1 June 2000
- journal article
- case report
- Published by Wiley in Psychiatry and Clinical Neurosciences
- Vol. 54 (3) , 379-380
- https://doi.org/10.1046/j.1440-1819.2000.00723.x
Abstract
A case of a 5‐year‐old boy with non‐24 hour sleep–wake syndrome and mental retardation is reported. His free‐running sleep–wake rhythm was remarkably improved by the oral administration of melatonin. The circadian variation in melatonin secretion was extremely low, and circadian rhythm of cortisol secretion was noted. It was speculated that his non‐24 hour sleep–wake syndrome was due to a congenital deficiency of melatonin secretion, and supplemental melatonin therapy proved effective for treating his condition.Keywords
This publication has 6 references indexed in Scilit:
- Daily melatonin intake resets circadian rhythms of a sighted man with non‐24‐hour sleep‐wake syndrome who lacks the nocturnal melatonin risePsychiatry and Clinical Neurosciences, 1997
- The amplitude of endogenous melatonin production is not affected by melatonin treatment in humansJournal of Pineal Research, 1997
- Non-24-Hour Sleep-Wake Syndrome in a Sighted Man: Circadian Rhythm Studies and Efficacy of Melatonin TreatmentSleep, 1996
- Melatonin treatment of a non-24-hour sleep-wake cycle in a blind retarded childBiological Psychiatry, 1995
- FALL IN NOCTURNAL SERUM MELATONIN DURING PREPUBERTY AND PUBESCENCEThe Lancet, 1984