The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11β-hydroxylase) inhibitors
- 27 June 2005
- journal article
- Published by Elsevier in The Journal of Steroid Biochemistry and Molecular Biology
- Vol. 96 (3-4) , 259-270
- https://doi.org/10.1016/j.jsbmb.2005.04.032
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Synthesis of Amidinohydrazones and Evaluation of Their Inhibitory Effect towards Aldosterone Synthase (CYP11B2) and the Formation of Selected SteroidsArchiv der Pharmazie, 2004
- Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosisEuropean Journal of Medicinal Chemistry, 2003
- Different Regulation of Cardiac and Renal Corticosteroid Receptors in Aldosterone-salt Treated Rats: Effect of Hypertension and GlucocorticoidsJournal of Molecular and Cellular Cardiology, 2000
- Cardiac aldosterone production and ventricular remodelingKidney International, 2000
- The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart FailureNew England Journal of Medicine, 1999
- Adrenal zonation: clues from 11β-hydroxylase and aldosterone synthaseMolecular and Cellular Endocrinology, 1999
- YM116, 2-(1H-Imidazol-4-ylmethyl)-9H-carbazole, Decreases Adrenal Androgen Synthesis by Inhibiting Cl7-20 Lyase Activity in NCI-H295 Human Adrenocortical Carcinoma CellsThe Japanese Journal of Pharmacology, 1999
- Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitorsPharmacogenetics, 1995
- The NCI-H295 cell line: a pluripotent model for human adrenocortical studiesMolecular and Cellular Endocrinology, 1994
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976