Loss of Heterozygosity on the Short Arm of Chromosome 9 without p16 Gene Mutation in Gastric Carcinomas
- 1 April 1995
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 86 (4) , 333-335
- https://doi.org/10.1111/j.1349-7006.1995.tb03060.x
Abstract
A putative tumor suppressor gene, p16 (MST1; multiple tumor suppressor 1/CDK4I; cyclin‐dependent kinase 4 inhibitor), was isolated and mapped on the short arm of chromosome 9 (9p). The significance of p16 mutations in gastric tumorigenesis was examined by assessing p16 mutations as well as loss of heterozygosity (LOH) on 9p in 13 gastric adenomas and 45 adenocarcinomas. LOH on 9p (IFNA; α‐interferon locus) was detected in 22% (5/23 informative cases) of differentiated adenocarcinomas, 10% (1/10) of undifferentiated carcinomas and none (0/6) of the adenomas. Although we found a sequence polymorphism at the second position of codon 99 (CGC/CAC) of the p16 in one gastric adenoma patient, no somatic mutations were detected in any of the gastric adenomas or adenocarcinomas. These results suggest that p16 mutations probably do not contribute to gastric tumorigenesis. However, these data suggest that another tumor suppressor gene on 9p (near the IFNA locus) may contribute to the progression of differentiated adenocarcinoma of the stomachKeywords
This publication has 13 references indexed in Scilit:
- Rates of p16 ( MTS1 ) Mutations in Primary Tumors with 9p LossScience, 1994
- Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.1994
- Open questions on p16Nature, 1994
- P16 gene in uncultured tumoursNature, 1994
- Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancersNature, 1994
- Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.1994
- Homozygous deletions within human chromosome band 9p21 in melanoma.Proceedings of the National Academy of Sciences, 1992
- Dinucleotide repeat polymorphism at the IFNA locus (9p22)Human Molecular Genetics, 1992
- Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas.1992
- p53 Mutations in Human CancersScience, 1991