Lymphocyte Density Distribution Profile and Spontaneous Transformation Related to the Stage of Hodgkin's Disease

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Abstract
Density distribution profiles of peripheral lymphocytes were made in 41 untreated patients with Hodgkin''s disease and in 14 normal controls. The fraction of lymphocytes with a low specific gravity in patients was significantly increased in comparison to normal controls (P = 0.0007). These low density lymphocytes in Hodgkin''s disease patients showed an elevated spontaneous 3H-thymidine incorporation compared to normal controls (P < 0.0001). In 78% of the patients spontaneous DNA synthesis of the low density lymphocytes was above the normal range. A positive correlation (P = 0.002) was found between the spontaneous 3H-thymidine uptake and the stage of the disease.