RETROSPECTIVE VALIDATION OF A NEW STAGING SYSTEM FOR WILMS TUMOR

  • 1 January 1981
    • journal article
    • research article
    • Vol. 4  (2) , 167-171
Abstract
Prognostic significance has been ascribed to certain clinicopathologic features of the Wilm''s tumor. Examples are size, vascular invasion, histologic characteristics, tumor rupture and lymph nodal involvement. Several of these were arranged into a grouping system and used in a cooperative clinical trial, the 1st National Wilms'' Tumor Study (NWTS) [USA]. Detailed clinicopathologic information was accumulated for each patient entered in the study; these data were analyzed with respect to their prognostic import. Factors found to be of significance were rearranged into a proposed staging system, believed more likely to be predictive of outcome for patients with tumor spread beyond the kidney confines, but without distant metastases (Groups II and III). The postulated discriminatory superiority was tested using Group II and III patients entered in the 2nd NWTS. The same children were reassigned retrospectively to Stages II and III and the outcomes compared. Statistically significant differences were noted between Stages II and III, but not for Groups II and III. These results encourage the use of the new staging system in the 3rd NWTS.

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