Hepatitis and Pneumonia Associated with ECHO Virus, Type 9, Infection in Two Adult Siblings

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Abstract
Two reports of pneumonia associated with ECHO virus, type 9, infection in 2 adult siblings is presented. Other manifestations of this infection consisted of aseptic meningitis in the brother and hepatitis in his sister. These patients were afflicted consecutively with febrile illnesses and ECHO-9 virus was isolated from the pharyngeal secretions of both patients. A significant increase of the homologous neutralizing antibody was demonstrated in the serum of the sister but not in her brother, possibly because the acute phase serum was obtained too late in his illness. The need to consider enteroviruses as being associated with pneumonia and hepatitis is emphasized.

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