INVITRO RESPONSE OF PLASMODIUM-FALCIPARUM TO CHLOROQUINE IN THE NANDI DISTRICT, KENYA

  • 1 January 1985
    • journal article
    • research article
    • Vol. 63  (3) , 593-595
Abstract
Isolates of P. falciparum from Nandi district, Kenya, which were tested for their sensitivity to chloroquine using the WHO in vitro macrotechnique, yielded a total of 29 successful tests, one of which showed overt resistance with schizont maturation at chloroquine levels of > 1.5 .times. 10-6 mol/l. The majority of isolates showed reduced sensitivity to chloroquine, and the EC99 [99% effective concentration] was 1.7218 .times. 10-6 mol/l. These findings are indicative of widespread in vitro resistance of a low degree which may remain largely unnoticed in immune individuals. However, in nonimmune subjects one may expect also in vivo resistance because the parasites will not be completely cleared after a normally curative dose of chloroquine.