Triggering of the lethal hit in human cytotoxic T lymphocytes: a functional role for a 103‐kDa T cell‐ specific activation antigen

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Abstract
A monoclonal antibody (CB.1) is described that defines a new triggering signal for human cytotoxic T lymphocytes (CTL). The antibody precipitates a 103‐kDa surface antigen from activated normal human T cells. The antigen is undetectable or present in only low amounts on resting T lymphocytes but its expression increases strongly after activation and proliferation on T4+ and T8+ T lymphocytes. Binding of antibody CB.1 to CTL results in triggering of the lethal hit. This induction of cytotoxicity is dependent on cross‐linking of CTL and an Fc receptor‐bearing target cell with CB.1 and requires Ca2+ like antigen‐specific triggering. CB.1‐induced triggering can be specifically inhibited by binding of antibodies to the T8 or T4 molecules on T8+ or T4+ CTL.

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