Differences in the effects of post-trial chlorpromazine, reserpine, and amphetamine on discrimination learning in rats

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Abstract
Rats were trained to perform in discrimination learning reinforced by water for 6 days, and were intraperitoneally injected with chlorpromazine, reserpine, or d-amphetamine after each training session. Although chlorpromazine at the dose levels of 0.5 mg/kg or more injected immediately after training impaired learning, the drug did not affect learning when it was injected 60 min after training. Reserpine and amphetamine also impaired learning, but delaying the time intervals between training and injection to 60 min or more had no influence on this learning impairment. Post-trial chlorpromazine and amphetamine had no effect on, but reserpine decreased, motility in the subsequent training session. Chlorpromazine had no effect on water intake in the subsequent session, but reserpine and amphetamine decreased water intake at the dose levels that impaired learning. It was concluded that all three drugs impaired learning, but differed in their effects on learning; chlorpromazine impaired learning by a specific effect on learning itself; reserpine, by a non-specific effect on behavior due to a long acting sedation; and amphetamine, by an effect to decrease the motivation to drink water. The specific effect of chlorpromazine could be related to the hypothesis of “memory trace” synthesis.