Increased colonic mucosal mast cells associated with severe watery diarrhea and microscopic colitis
- 1 September 1989
- journal article
- case report
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 34 (9) , 1462-1465
- https://doi.org/10.1007/bf01538086
Abstract
Summary A patient with microscopic colitis, clearly identifiable by its histologic characteristics, is presented in whom the histology also revealed large numbers of mast cells. The patient was treated with H1 antagonists with prompt resolution of the diarrhea. The histologic and therapeutic findings in this case suggest the diarrhea and inflammation of microscopic colitis may be mediated by the degranulation of excessive numbers of mast cells in the colon and small bowel.Keywords
This publication has 9 references indexed in Scilit:
- An evaluation of the significance of microscopic colitis in patients with chronic diarrhea.Journal of Clinical Investigation, 1985
- Mast Cell Heterogeneity in ManInternational Archives of Allergy and Immunology, 1985
- MastocytosisJournal of Allergy and Clinical Immunology, 1984
- Effects of histamine and histamine receptor antagonists on ion transport in rabbit descending colonAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1984
- Neural and Pharmacologic Factors Affecting Motility of the Internal Anal SphincterGastroenterology, 1983
- Microscopic colitis-a cause of chronic watery diarrhoea.BMJ, 1982
- Human intestinal mucosal mast cells: evaluation of fixation and staining techniques.Journal of Clinical Pathology, 1981
- Mesenteric vascular reactivity to histamine receptor agonists and antagonistsDigestive Diseases and Sciences, 1981
- Role of histamine H1- and H2-receptors in myoelectric activity of small bowel in the dogAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1980