REDUCTION OF NORMAL CEREBROSPINAL FLUID PRESSURE BY INTRAVENOUS ADMINISTRATION OF HYPERTONIC SOLUTIONS
- 1 September 1925
- journal article
- other
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 14 (3) , 315-326
- https://doi.org/10.1001/archneurpsyc.1925.02200150028003
Abstract
In 1919, Weed and McKibben1called attention to the fact that it was possible to decrease the pressure of the cerebrospinal fluid experimentally by the intravenous injection of hypertonic solutions. Since the publication of their paper a number of workers have confirmed their findings and contributed some further observations. Haden2was the first to publish his clinical application of this principle. He administered a concentrated glucose solution to two patients with meningitis and obtained some improvement in their condition, which he attributed to a lowering of the intracranial tension. Cushing and Foley3followed this with a demonstration of the possibility of decreasing the brain volume by the intravenous injection of hypertonic solutions. These authors further found that a similar diminution in brain bulk and decrease in intracranial pressure could be obtained by the introduction of hypertonic solutions into the stomach or intestine. Hypotonic solutions, which had beenKeywords
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