Identification of 3β, 7α-Dihydroxychol-5-enoic Acid in Fistula Bile of the Rat Given Cholesterol-4-14C and DL-Mevalonate-2-14C
- 1 January 1972
- journal article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 71 (1) , 85-89
- https://doi.org/10.1093/oxfordjournals.jbchem.a129749
Abstract
A Lifschütz positive compound was found in the bile of bile-fistula rats injected with mevalonate-14C or with cholesterol-14C. This compound was identified as 3β, 7α-dihydroxychol-5-enoic acid by thin-layer chromatography and radio-isotope dilution experiments. This finding was taken for a further evidence favorable for a new pathway of chenodeoxycholic acid biogenesis proposed by the authors.Keywords
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