Inhibition by Methylmalonate of Glycine Uptake by Synaptosomes from Rat Spinal Cord
- 1 January 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 36 (1) , 325-327
- https://doi.org/10.1111/j.1471-4159.1981.tb02416.x
Abstract
Methylmalonate and glycine are accumulated in the genetically linked deficiency of methylmalonyl-CoA mutase (methylmalonic acidemia). Inhibition of synaptosomal glycine uptake by methylmalonate at similar concentrations to methylmalonic acidemia is reported. This inhibition may be responsible, at least in part, for the neurological damage characteristic of this disease, by increasing the glycine levels in the synaptic cleft and interfering with the normal function of the inhibitory glycinergic synapsis in the spinal cord.Keywords
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