Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in Sardinia
Open Access
- 20 January 2008
- journal article
- Published by Springer Nature in BMC Medical Genetics
- Vol. 9 (1) , 3
- https://doi.org/10.1186/1471-2350-9-3
Abstract
The Mediterranean island of Sardinia has a strikingly high incidence of the autoimmune disorders Type 1 Diabetes (T1D) and Multiple Sclerosis (MS). Furthermore, the two diseases tend to be co-inherited in the same individuals and in the same families. These observations suggest that some unknown autoimmunity variant with relevant effect size could be fairly common in this founder population and could be detected using linkage analysis.Keywords
This publication has 29 references indexed in Scilit:
- Risk Alleles for Multiple Sclerosis Identified by a Genomewide StudyNew England Journal of Medicine, 2007
- Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosisNature Genetics, 2007
- Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetesNature Genetics, 2007
- Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4PLoS Genetics, 2007
- Type 1 Diabetes and Multiple SclerosisArchives of Neurology, 2006
- Type 1 DiabetesDiabetes, 2005
- The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region aloneHuman Molecular Genetics, 2004
- A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetesNature Genetics, 2004
- A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.Human Molecular Genetics, 2001
- Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locusNature Genetics, 1995