Clinical Application of Blood Transketolase Determinations
- 20 September 1962
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 267 (12) , 596-598
- https://doi.org/10.1056/nejm196209202671204
Abstract
A NUMBER of biochemical tests have been designed and employed to aid in the overall assessment of the nutritional state of patients thought to be suffering from a vitamin deprivation. Many of these tests are cumbersome and poorly reproducible, and some lack specificity. In 1953 Horecker and Smyrniotis1 and Racker et al.2 independently discovered that transketolase, one of the enzymes of the hexose-monophosphate shunt, required thiamine pyrophosphate as cofactor. This enzyme, which has been found to exist in a number of mammalian tissues, acts as catalyst in the following steps: Both Brin and his associates3 and Bruns4 have demonstrated the . . .Keywords
This publication has 5 references indexed in Scilit:
- On the Etiology of the Alcoholic Neurologic DiseasesThe American Journal of Clinical Nutrition, 1961
- The Effect of Thiamine Deficiency on the Activity of Erythrocyte Hemolysate TransketolaseJournal of Nutrition, 1960
- QUALITATIVE AND QUANTITATIVE COLORIMETRIC DETERMINATION OF HEPTOSESJournal of Biological Chemistry, 1953
- THIAMINE PYROPHOSPHATE, A COENZYME OF TRANSKETOLASEJournal of the American Chemical Society, 1953
- THE COENZYME FUNCTION OF THIAMINE PYROPHOSPHATE IN PENTOSE PHOSPHATE METABOLISMJournal of the American Chemical Society, 1953