Anticonvulsant Properties of l-Glutamine and l-Asparagine in Mice and Rats.

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Abstract
Two amides, 1-glutamine and 1-asparagine, were tested for anticonvulsant activity in mice after acute administration by a battery of 6 anticonvulsant assay procedures and after chronic administration by 3 tests. In addition, both agents were tested in mice for ability to prevent methionine sulfoximine-induced seizures and in rats for ability to elevate the minimal electroshock seizure threshold lowered by food restriction. Results indicate that both these agents are virtually devoid of anticonvulsant activity as measured by a number of diverse laboratory screening procedures.