Norfloxacin--a review of pharmacology and tissue penetration
- 1 January 1984
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 13 (suppl B) , 59-64
- https://doi.org/10.1093/jac/13.suppl_b.59
Abstract
A review of the pharmacokinetics of the highly active quinoline derivative, norfloxacin, is presented. The compound appears to be rapidly absorbed. The serum half-life is about 3.5 h and 30% of a given dose is recovered in the urine. Rapid penetration of an inflammatory exudate occurs. The compound is metabolized to a modest extent, probably in the liver, six metabolites being recogniied. The serum half-life is prolonged in severe renal impairment. Probenecid would appear to decrease the renal elimination. The possibility of treating both urinary and tissue infections with this compound is raised.Keywords
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