Phospholipids Chiral at Phosphorus. 13. Stereochemical Comparison of Phospholipase A2, Lecithin-Cholesterol Acyl Transferase, and Platelet-Activating Factor
- 1 April 1987
- journal article
- research article
- Published by Taylor & Francis in Phosphorus and Sulfur and the Related Elements
- Vol. 30 (3-4) , 601-604
- https://doi.org/10.1080/03086648708079137
Abstract
Thiophospholipids and thiophosphate analogs of platelet activating factor were synthesized and used to compare the stereochemical properties in three different biological systems. Phospholipase A2 shows high stereo-specificity, and this has been substantiated by computer graphics. Lecithin-cholesterol acyl transferase shows no stereospecificity. Platelet aggregation shows, preliminarily, a small degree of stereospecificity.Keywords
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