Frequency of Renin Gene Restriction Fragment Length Polymorphism in Hypertensives with a Genetic Predisposition to Hypertension
- 1 January 1994
- journal article
- research article
- Published by S. Karger AG in Hormone Research
- Vol. 41 (5-6) , 218-221
- https://doi.org/10.1159/000183927
Abstract
The genetic basis of essential hypertension is still uncertain. Because renin is thought to be a candidate gene for essential hypertension, a prospective study was conducted to compare the frequency of renin gene HindIII restriction fragment length polymorphism (RFLP) in normotensive and hypertensive subjects without (HTG-) and with a genetic predisposition to essential hypertension (HTG+). The frequency of the 9.0-kb fragment was significantly (p < 0.05) higher in the HTG+ group than in the normotensive and HTG- groups. An association between renin RFLP and hypertension in man was shown for the first time. It is suggested that a gene for blood pressure regulation has been localized to a part of the genome close to, or identical to, the renin locus.Keywords
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