THE USE OF THE OVARIAN ASCORBIC ACID DEPLETION TEST FOR MEASURING LUTEINIZING HORMONE IN HUMAN URINE

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Abstract
SUMMARY: The possibility of applying the ovarian ascorbic acid depletion assay or its variants to the measurement of luteinizing hormone in human urine extracts has been investigated. A 3 hr. i.v. technique proved the most sensitive. The method had limitations as a clinical assay, namely: a relatively low degree of precision, toxicity of some urinary extracts and the fact that about 20 % of assays were invalid owing to a lack of parallelism. Two of ten patients with amenorrhoea and raised gonadotrophin levels showed a relative lack of FSH as compared with the International Reference Preparation for human menopausal gonadotrophin.

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