IMMUNOLOGICAL CLEARANCE OF SE-75-LABELED TRYPANOSOMA-BRUCEI IN MICE .2. MECHANISMS IN IMMUNE ANIMALS
- 1 January 1980
- journal article
- research article
- Vol. 40 (4) , 629-635
Abstract
Using trypanosomes labeled with [75Se]-methionine experiments were conducted to investigate the respective roles of antibody, macrophage activation and complement in the removal of trypanosomes from the circulation of immune mice. Clearance in such animals was largely accomplished by antibody-mediated hepatic phagocytosis, which, at least in passively immunized animals, is dependent on opsonization involving C3 [complement component 3]. No evidence was found to suggest that intravascular lysis or activated macrophages are involved in immune clearance.This publication has 15 references indexed in Scilit:
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