T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
Top Cited Papers
- 24 August 2003
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 9 (9) , 1123-1124
- https://doi.org/10.1038/nm921
Abstract
Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.Keywords
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