STUDY OF THE EFFECT OF POVIDONE-IODINE ON POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 60  (6) , 662-666
Abstract
Studies were made of the effect of povidone-iodine [an antiseptic] on human polymorphonuclear leukocyte chemotaxis. Polymorphonuclear leukocytes were incubated with various concentrations of povidone-iodine and allowed to migrate across a membrane towards a chemotactic agent. Chemotactic movement was found to decrease as the concentration of povidone-iodine rose, 75 .mu.g/ml completely inhibiting all movement. A concentration of 100 .mu.g/ml of povidone-iodine was found actively to repel the white cells. In vivo studies in mice showed a reduction in polymorphonuclear leukocytes at wound surfaces in the presence of povidone-iodine dry powder spray.