In Vitro Activities of Iboga Alkaloid Congeners Coronaridine and 18-Methoxycoronaridine againstLeishmania amazonensis
Open Access
- 1 July 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (7) , 2111-2115
- https://doi.org/10.1128/aac.46.7.2111-2115.2002
Abstract
In previous studies, we demonstrated the leishmanicide effect of coronaridine, a natural indole alkaloid isolated from stem bark ofPeschiera australis(Delorenzi et al., Antimicrob. Agents Chemother.45:1349-1354, 2001). In this study we show the leishmanicidal effect of the synthetic coronaridine and its racemic 18-methoxylated analog, 18-methoxycoronaridine. Both alkaloids revealed a potent leishmanicide effect againstLeishmania amazonensis, a causative agent of cutaneous and diffuse cutaneous leishmaniasis in the New World. Despite their potent leishmanicide effect, both alkaloids were neither toxic to murine macrophages nor did they modulate their oxidative or cytokine production responses.Keywords
This publication has 41 references indexed in Scilit:
- Antileishmanial Activity of an Indole Alkaloid fromPeschiera australisAntimicrobial Agents and Chemotherapy, 2001
- Leishmania–HIV Interaction: Immunopathogenic MechanismsParasitology Today, 1999
- Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.The Journal of Experimental Medicine, 1996
- Comparison of the Hallucinogenic Indole Alkaloids Ibogaine and Harmaline for Potential Immunomodulatory ActivityPharmacology, 1995
- Chemical Constituents and Pharmacological Activities ofPeschiera australisInternational Journal of Pharmacognosy, 1993
- Effects of ibogaine on acute signs of morphine withdrawal in rats: Independence from tremorNeuropharmacology, 1992
- A common intermediate providing syntheses of .PSI.-tabersonine, coronaridine, iboxyphylline, ibophyllidine, vinamidine, and vinblastineThe Journal of Organic Chemistry, 1992
- Heyneanine Hydroxyindolenine, A New Indole Alkaloid from Ervatamia coronaria var. plenaJournal of Natural Products, 1988
- Total synthesis of indole and dihydroindole alkaloids. IV. Total synthesis of dl-dihydrocleavamine, dl-carbomethoxydihydrocleavamine, dl-coronaridine, dl-dihydrocatharanthine, and dl-ibogamine. General entry into the iboga and vinca alkaloidsJournal of the American Chemical Society, 1970
- Alkaloids from Apocynaceae. III.1 Alkaloids of Tabernaemontana and Ervatamia. The Structure of Coronaridine, A New Alkaloid Related to Ibogamine2Journal of the American Chemical Society, 1960