Vascular Access and All-Cause Mortality
Top Cited Papers
- 1 February 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of the American Society of Nephrology
- Vol. 15 (2) , 477-486
- https://doi.org/10.1097/01.asn.0000109668.05157.05
Abstract
Objective To determine the effect of vitamin D3 on interferon-β (IFN-β) response and immune regulation in MS mononuclear cells (MNCs). Methods MNCs from 126 subjects, including therapy-naive patients with different forms of MS, plus patients with MS receiving IFN-β or glatiramer treatment, plus healthy controls were incubated in vitro with IFN-β-1b ± vitamin D3 (calcitriol). Activation of the IFN-β–induced transcription factor, p-Y-STAT1, and antiviral myxovirus A (MxA) protein was measured with flow cytometry and Western blots; serum proteins were measured with a customized 31-protein multiplex assay. Results Vitamin D enhanced in vitro IFN responses, as measured by induction of p-Y-STAT1 and MxA in MNCs, T cells, and monocytes. Vitamin D augmentation of IFN responses was seen in untreated and in IFN-β-1b–treated MS. The combination of vitamin D plus IFN-β reduced Th1 and Th17 cytokines, and increased Th2 responses, reversing the effect of IFN-β alone. Exacerbations and progression in untreated patients reduced the vitamin D enhancement of IFN responses. Vitamin D had less effect on IFN response in clinically stable glatiramer-treated than in IFN-β–treated patients. Conclusion Vitamin D enhances IFN-β induction of multiple proteins and also reverses the Th1/Th2 bias in MS seen with IFN-β alone. The combination of vitamin D and IFN-β has potential benefit in ameliorating MS.Keywords
This publication has 17 references indexed in Scilit:
- Epidemiology of vascular access in the Australian hemodialysis populationKidney International, 2003
- A Propensity Analysis of Late Versus Early Nephrologist Referral and Mortality on DialysisJournal of the American Society of Nephrology, 2003
- Vascular access and increased risk of death among hemodialysis patientsKidney International, 2002
- Type of vascular access and mortality in U.S. hemodialysis patientsKidney International, 2001
- III. NKF-K/DOQI Clinical Practice Guidelines for Vascular Access: Update 2000American Journal of Kidney Diseases, 2001
- Cross-sectional and longitudinal predictors of serum albumin in hemodialysis patientsKidney International, 2000
- Hemodialysis access failure: A call to actionKidney International, 1998
- Estimating Causal Effects from Large Data Sets Using Propensity ScoresAnnals of Internal Medicine, 1997
- The central role of the propensity score in observational studies for causal effectsBiometrika, 1983
- Partial residuals for the proportional hazards regression modelBiometrika, 1982