RATE OF EXCRETION OF URINARY ANDROGENS AFTER ADMINISTRATION OF TESTOSTERONE BY VARIOUS ROUTES1

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Abstract
Single doses of testosterone propionate, 10 to 240 mg., were given 2 castrate men orally and intramusc. in oil. One subject was given 90 and 270 mg. implanted subcut. Augmentation of urinary androgenic activity was detectable for several days. Inj. of 20 mg. in peanut oil appeared the minimal amt. for maintaining urinary androgenic excretion at an avg. normal level. Phenomena characteristic of castration were absent when the urinary androgenic activity was within the range found in young adults. With all oral doses employed an increase in urinary titer occurred within 2 hrs. The time required for both inactivation and excretion was short, the major urinary elevation having disappeared after 10 hrs. The data suggest no renal threshold for androgen.