Abstract
From the hypothesis that treatment with small negative air ions causes a depletion of brain 5-hydroxytryptamine, it is predicted that a measure of mood or emotion will be affected by air ion treatment. The conditioned emotional response technique described by Brady provided the dependent variable. Results of 2 experiments, the 2nd essentially a replication of the 1st, are in accordance with the prediction. The inhibition of response in the animal was reduced by treatment with small negative air ions, as it was with reserpine.

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