The Agglutination of Intact Azo-Erythrocytes by Antisera Homologous to the Attached Groups

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Abstract
Summary: It has been shown that sheep erythrocytes to which azophenylarsonate groups have been attached are agglutinated by anti-azophenylarsonate rabbit serum; the fact that this agglutination occurs when as few as about sixty arsonate groups per cell are present provides evidence that the cells need not be covered by antibody in order for agglutination to take place. It was also observed that erythrocytes to which ovalbumin has been attached through reaction with bisdiazotized benzidine are agglutinated by anti-ovalbumin serum. Bisdiazotized benzidine itself slowly agglutinates erythrocytes, presumably through the formation of azobiphenylazo linkages between cells. Azo-erythrocytes with attached azophenylarsonate groups or ovalbumin-molecules can be agglutinated by anti-erythrocyte serum as well as by anti-azophenylarsonate or antiovalbumin serum.

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