Effect of Topical NSAID on Post-Exercise Jaw Muscle Soreness:

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Abstract
Objectives: To develop an experimental model to induce soreness in jaw muscles. To assess the efficacy of a topical nonsteroidal anti-inflammatory drug [NSAID] on this muscle soreness. Methods: Ten subjects participated in a two-part, double-blind, placebo-controlled, cross-over study each lasting 7 days. Topical NSAID [Dolgit, 5% ibuprofen gel, Dolorgiet GmbH, Bonn, Germany] and placebo gels were applied over the masseter muscles and over the temporomandibular joints [TMJ] 3 times a day for 4 days follwed by an exercise day. On this day repeated pressure-pain thresholds [PPT], maximal voluntary isometric contractions [MVC], clenches to endurance, and eccentric open-close jaw movements were performed. The two following post-exercise days, topical NSAID or placebo was applied. The design of the study allowed an evaluation of the preemptive and postemptive effect of NSIAD.