Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
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- 1 July 2002
- journal article
- research article
- Published by Springer Nature in Nature Immunology
- Vol. 3 (8) , 741-748
- https://doi.org/10.1038/ni817
Abstract
FcεRI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that FcεRI also uses a Fyn kinase–dependent pathway that does not require Lyn kinase or the adapter LAT for its initiation, but is necessary for mast cell degranulation. Lyn-deficiency enhanced Fyn-dependent signals and degranulation, but inhibited the calcium response. Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, FcεRI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases.Keywords
This publication has 48 references indexed in Scilit:
- Gain- and Loss-of-Function Lyn Mutant Mice Define a Critical Inhibitory Role for Lyn in the Myeloid LineageImmunity, 2001
- Coupling of the TCR to Integrin Activation by SLAP-130/FybScience, 2001
- A Perspective: Regulation of IgE Receptor-Mediated Mast Cell Responses by a LAT-Organized Plasma Membrane-Localized Signaling ComplexInternational Archives of Allergy and Immunology, 2001
- THE HIGH-AFFINITY IgE RECEPTOR (FcεRI): From Physiology to PathologyAnnual Review of Immunology, 1999
- A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human NeutrophilsPublished by Elsevier ,1996
- Augmented humoral and anaphylactic responses in FcγRII-deficient miceNature, 1996
- New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL)Immunology Today, 1995
- Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient miceImmunity, 1995
- Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinasesNature, 1992
- Studies with a monoclonal antibody to the β subunit of the receptor with high affinity for immunoglobulin EMolecular Immunology, 1988