Metabolic Products ofN-Ethyl-β-methoxy-β-(3'-trifluoromethylphenyl)ethylamine (SKF 40652A)
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 7 (9) , 537-547
- https://doi.org/10.3109/00498257709038689
Abstract
The metabolism of N-ethyl-β-methoxy-β-(3'-trifluoromethyrphenyl)ethylamine (SKF 40652A, I) in vitro with 9000 g supernatants and washed microsomes of rabbit liver gave N-dealkylation, and N-oxidation of the parent secondary amine and the derived primary amine, anti and syn β-methoxy-β-(3'-trifluoromethylphenyl)acetaldoximes (V), and the β-methoxy-β-(3'-trifluoromethylphenyl)ethyl alcohol (VI). The identification and the physicochemical properties of these compounds are reported.This publication has 13 references indexed in Scilit:
- Metabolic incorporation of oxygen into primary and secondary aliphatic amines and the consequences in carbon-nitrogen bond cleavageJournal of Pharmacy and Pharmacology, 1975
- The Identification of Three New Metabolic Products of Phentermine after Liver Microsomal IncubationXenobiotica, 1974
- Metabolism of amphetamines. Identification of N-oxygenated products by gas chromatography and mass spectrometryJournal of Pharmacy and Pharmacology, 1973
- N-Oxidation of primary and secondary amines to give hydroxylamines—a general metabolic routeJournal of Pharmacy and Pharmacology, 1972
- The mechanism of oxidation of amphetamine enantiomorphs by liver microsomal preparations from different speciesJournal of Pharmacy and Pharmacology, 1972
- Metabolic Oxidation of Aliphatic Basic Nitrogen Atoms and their α-Carbon AtomsXenobiotica, 1971
- Fenfluramine MetabolismJournal of Pharmaceutical Sciences, 1968
- The fate of amphetamine in man and other mammalsJournal of Pharmacy and Pharmacology, 1966
- Anorexigenic Agents: Aromatic Substituted 1-Phenyl-2-propylaminesJournal of Medicinal Chemistry, 1963