Cell-Mediated Cytotoxicity: Comparison of Primary and Secondary Immune Reactions after Parainfluenza Type 1 Virus Inoculation

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Abstract
H-2 antigen compatibility of effector spleen cells and target cells was necessary for cell-mediated cytotoxicity (CMC) after both 1 and 2 intraperitoneal inoculations of 6/94 virus into mice. T cells were responsible for both primary and secondary CMC reactions. Neither reaction was influenced by the presence of virus-specific antibody added to the test system. Secondary CMC peaked earlier than the primary response and declined more rapidly. In vitro stimulation of primed spleen cells could also be used to detect the secondary CMC response.