Analysis of a zebrafish semaphorin reveals potential functions in vivo
Open Access
- 1 January 1999
- journal article
- research article
- Published by Wiley in Developmental Dynamics
- Vol. 214 (1) , 13-25
- https://doi.org/10.1002/(sici)1097-0177(199901)214:1<13::aid-dvdy2>3.0.co;2-3
Abstract
The semaphorin/collapsin gene family is a large and diverse family encoding both secreted and transmembrane proteins, some of which are thought to act as repulsive axon guidance molecules. However, the function of most semaphorins is still unknown. We have cloned and characterized several semaphorins in the zebrafish in order to assess their in vivo function. Zebrafish semaZ2 is expressed in a dynamic and restricted pattern during the period of axon outgrowth that indicates potential roles in the guidance of several axon pathways. Analysis of mutant zebrafish with reduced semaZ2 expression reveals axon pathfinding errors that implicate SemaZ2 in normal guidance. Dev Dyn 1999;214:13–25.Keywords
This publication has 61 references indexed in Scilit:
- A Novel Transmembrane Semaphorin Can Bind c-srcMolecular and Cellular Neuroscience, 1997
- Cloning and Expression of a Novel Murine Semaphorin with Structural Similarity to Insect Semaphorin IMolecular and Cellular Neuroscience, 1997
- Guidance of Circumferentially Growing Axons by Netrin-Dependent and -Independent Floor Plate Chemotropism in the Vertebrate BrainNeuron, 1996
- Identification of a Novel Transmembrane Semaphorin Expressed on LymphocytesPublished by Elsevier ,1996
- Growth cones and the cues that repel themTrends in Neurosciences, 1996
- Identification of a member of mouse semaphorin familyFEBS Letters, 1995
- Stages of embryonic development of the zebrafishDevelopmental Dynamics, 1995
- The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6Cell, 1994
- Development of reticulospinal neurons of the zebrafish. II. Early axonal outgrowth and cell body positionJournal of Comparative Neurology, 1986
- Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probesDevelopmental Biology, 1984