Inhibition of Adenylate Cyclase Activity in Human Fat Cells by α-Adrenergic Agonists
- 1 September 1982
- journal article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 14 (09) , 475-479
- https://doi.org/10.1055/s-2007-1019051
Abstract
The effects of the α1-adrenergic agonist methoxamine and the α2-adrenergic agonist clonidine on isoproterenol stimulated adenylate cyclase activity were examined in plasma membranes prepared from female human subcutaneous adipose tissue. It was found that in the presence of 10 μM GTP and 100 mM NaCl increasing concentrations of both agonists inhibited basal and isoproterenol-stimulated adenylate cyclase activity. The inhibitory action of 5 × 10-7 M clonidine could not be overcome by increasing concentrations of isoproterenol. These results suggest both α1- and α2-adrenergic agonists inhibit β-agonist-stimulated adenylate cyclase activity in human adipose tissue.Keywords
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