Allylation of Unactivated Ketones by Tetraallyltin Accelerated by Phenol. Application to Asymmetric Allylation Using a Tetraallyltin-BINOL System
- 1 August 1998
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 27 (8) , 743-744
- https://doi.org/10.1246/cl.1998.743
Abstract
The tetraallyltin-phenol system was mild and effective for allylation of unactivated ketones, giving tertiary alcohols in high yields. The asymmetric allylation was achieved by a tetraallyltin-homochiral BINOL (1,1′-bi-2-naphthol) system. The addition of methanol raised the enantioselectivity to afford the tertiary homoallylic alcohol up to 60% ee.Keywords
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