LONGITUDINAL-STUDY OF T-LYMPHOCYTES AND B-LYMPHOCYTES FROM A 3-YEAR-OLD PATIENT WITH SEVERE COMBINED IMMUNODEFICIENCY (SCID) IN GNOTOBIOTIC PROTECTION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 6  (2) , 129-134
Abstract
Fluctuations in the percentages and absolute numbers of T [thumus-derived] and B [bone marrow-derived] lymphocytes were observed in the peripheral blood of a patient with SCID maintained in a gnotobiotic environment. Up to 24 mo. of age, 72-86% of the lymphocytes had surface membrane immunoglobulin (SMIg), 37-47% bore a receptor for C3 [complement component 3] (EAC-RFC) and 3-12.5% formed spontaneous rosettes with sheep erythrocytes (E-RFC). These values persisted until 30 mo., after which shifts in the percentages and absolute numbers of T and B cells were observed. A significant decrease in the proportion of SMIg-bearing cells to 20-40% (169-405 mm3), and EAC-RFC to 10.5-39% (114-259 mm3), was accompanied by a general increase in the proportion of T cells to 19-60% (141-1026 mm3), representing a lymphoid subpopulation approach to normal levels.

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