Diabetes Mellitus

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Abstract
IN this report the following aspects of diabetes mellitus are considered: biochemistry and physiology; insulin and its metabolism; endocrine effects; pathology and pathogenesis; diagnosis; clinical diabetes; therapy, insulin and hypoglycemic sulfonamides; pregnancy and diabetes; and complications.Carbohydrate MetabolismExperimental diabetes has continued to shed light on the biochemical defects of human diabetes. Several sites have been suggested for these defects.† It is not always easy to distinguish between the various possibilities and to decide which defects are primary and which secondary effects of the diabetic state.In a previous review,3 evidence for a diabetic defect in transfer of glucose across . . .

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