In vitro susceptibility of diarrhoea producing Gram negative enteric bacteria to sulfasalazine, 5‐aminosalicylic acid, sulfapyridine and four quinolones

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Abstract
The in vitro susceptibility of diarrhoea producing Gram negative enteric bacteria to sulfasalazine, 5-aminosalicylic acid, sulfapyridine and four quinolones was investigated using an agar dilution method. All strains were resistant to 1600 .mu.g/ml of sulfasalazine and 5-aminosalicyclic acid. MIC range of sulfapyridine for Yersinia enterocolitica was 3.1-25 .mu.g/ml (median: 6.2) and for Salmonella 25-100 .mu.g/ml (median: 100); Campylobacter jejuni/coli were less susceptible to sulfapyridine with MIC values ranging from 200 to 800 .mu.g/ml. Shigella and three of five Escherichia coli strains were resistant to 1600 .mu.g/ml of sulfapyridine. Two strains of E. coli were inhibited by 25 .mu.g/ml. All strains were fairly susceptible to enoxacin, ciprofloxacin, pefloxacin and ofloxacin. Ciprofloxacin was the most active drug on weight basis.