Electrophoresis of platelet monoamine oxidase in schizophrenia and manic-depressive illness

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Abstract
Monoamine oxidase (MAO) is an important enzyme in the catabolism of biogenic amines and can be measured in human platelets. Platelet MAO was reported to be reduced in schizophrenic and manic-depressive patients, although other reports are contradictory. The present study evaluated the possibility that qualitative genetic enzyme abnormalities of MAO could be responsible for the different enzyme activities of platelet MAO in different populations. Polyacrylamide gel electrophoresis of platelet MAO from 10 manic-depressive, 12 schizophrenic and 11 normal individuals did not reveal any genetic mutant forms.