A Comparison of Tetrahydrofolate and 5-Formyltetrahydrofolate in Correcting the Impairment of Thymidine synthesis in Pernicious Anaemia

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Abstract
5-Formyltetrahydrofolate and tetrahydrofolate were added to marrow cells from patients with untreated pernicious anemia at 1-, 5- and 50-nmol doses in the deoxyuridine suppression test. At all 3 dose levels, formyltetrahydrofolate was significantly more effective in correcting the defect of thymidine synthesis in pernicious anemia than was tetrahydrofolate. Formylation of tetrahydrofolate is apparently necessary for its normal utilization.