Histometric evaluation of the effect of nicotine administration on periodontal breakdown: an in vivo study

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Abstract
The present study investigated the effect of nicotine administration on periodontal breakdown resulting from ligature‐induced periodontitis in rats. Twenty adult male Wistar rats were used. After anesthesia, a mandibular first molar was randomly assigned to receive a cotton ligature in the sulcular area while the contralateral tooth was left unligated. The animals were randomly assigned to one of the following treatments, of daily intraperitoneal injections: A – saline solution, B – 0.37 mg of nicotine/kg, C – 0.57 mg of nicotine/kg and D – 0.73 mg of nicotine/kg. Thirty days later, the animals were sacrificed and the specimens routinely processed for serial decalcified sections. Statistical analysis (ANOVA) revealed greater bone loss (pp<0.05). Therefore, daily administration of nicotine enhanced, in a dose‐dependent manner, the effects of local factors in producing periodontal breakdown. Furthermore, the nicotine seemed to have a direct deleterious effect on the periodontal tissues.

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