Chemotherapy of an Experimental Fusobacterium ( Sphaerophorus ) necrophorum Infection in Mice
- 1 June 1974
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 5 (6) , 658-662
- https://doi.org/10.1128/aac.5.6.658
Abstract
An experimental animal model for testing antibiotics in vivo against Fusobacterium ( Sphaerophorus ) necrophorum has been developed. It incorporates the subcutaneous injection of the bacteria into mice followed by intraperitoneal administration of the antibiotic at 24, 48, 72, and 96 h. Mean effective dose values are based on the number of survivors 21 days after challenge. Tetracycline was the most effective drug tested, with a mean effective dose of 5.0 mg/kg, compared with mean effective dose values of 11.1 for clindamycin, 11.8 for penicillin-G, and 52.9 for lincomycin.Keywords
This publication has 8 references indexed in Scilit:
- Clindamycin in the Treatment of Serious Anaerobic InfectionsAnnals of Internal Medicine, 1973
- Treatment of severe bacteroides infections with parenteral clindamycin.1972
- Treatment of Anaerobic Infections with Lincomycin and ClindamycinNew England Journal of Medicine, 1972
- Standardized Single-Disc Method for Antibiotic Susceptibility Testing of Anaerobic BacteriaAntimicrobial Agents and Chemotherapy, 1972
- “Bacteroides” bacteremiaThe American Journal of Medicine, 1971
- Clinical investigations of infectious foot rot of cattle.1969
- Phosphonomycin. V. Evaluation in mice.1969
- The effect of chlortetracycline, fed continuously during fattening, on the incidence of liver abscesses in beef cattle.1958