Abstract
Recent progress in synthetic chemistry of cyclic ether derivatives has been reviewed. Newly developed methods especially for the stereocontrolled construction of seven- and eight-membered cyclic ether derivatives are described. These include (1) direct cyclization method from alcohols, (2) synthesis from lactones, (3) intramolecular alkylation method, (4) ring enlargement method, (5) reductive synthesis from bicyclic ketals.

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