Adaptations in Skeletal Muscle Disuse or Decreased-Use Atrophy

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Abstract
Edgerton VR, Roy RR, Allen DL, Monti RJ: Adaptations in skeletal muscle disuse or decreased-use atrophy. Am J Phys Med Rehabil 2002;81(Suppl):S127–S147. Those factors that seem to play some role in inducing adaptations of skeletal muscle in vivo are discussed. The role of myogenesis in maintaining and repairing muscle during atrophic and hypertrophic states is discussed, including pointing out that the modulation of myonuclear number is one means of adapting to varying chronic levels of neuromuscular activity. Finally, we point out the potential consequences of muscle atrophy on the control of movement and the susceptibility to fatigue.