Evidence for the presence of two tumour-suppressor genes for hepatocellular carcinoma on chromosome 13q
Open Access
- 1 August 1995
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 72 (2) , 383-385
- https://doi.org/10.1038/bjc.1995.342
Abstract
The concept that genetic changes accumulate during development and progression of cancer is widely accepted. Frequent allelic losses at chromosome 13q have been found in hepatocellular carcinomas (HCCs), and a known tumour-suppressor at 13q14, the retinoblastoma (RB) gene, is thought to be the target of those events. However, no strong evidence has emerged to support a significant role of RB during hepatocarcinogenesis. To investigate the minimal area(s) of loss on chromosome 13q in HCCs, we analysed DNAs isolated from 92 tumours for loss of heterozygosity (LOH) at 13 loci on chromosome 13q, using polymorphic microsatellite markers. In 30 (32.6%) of 92 cases we detected LOH for at least one locus on chromosome 13q and 20 revealed a partial or interstitial deletion of chromosome 13q. Deletion mapping of these 20 tumours indicated two separate commonly deleted regions: one was located in the region including RB and the other was located in the region including the BRCA2 locus. These findings suggest that at least one putative tumour-suppressor gene for HCC other than RB, possibly BRCA2, exists on chromosome 13q.Keywords
This publication has 19 references indexed in Scilit:
- The 1993–94 Généthon human genetic linkage mapNature Genetics, 1994
- Allelotype of human ovarian cancer.1991
- Loss of somatic heterozygosity in hepatocellular carcinoma.1991
- Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas.1991
- Allelotype study of primary hepatocellular carcinoma.1991
- ALLELOTYPE OF BREAST-CANCER - CUMULATIVE ALLELE LOSSES PROMOTE TUMOR PROGRESSION IN PRIMARY BREAST-CANCER1990
- Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.Proceedings of the National Academy of Sciences, 1990
- Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma.Proceedings of the National Academy of Sciences, 1989
- Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.Proceedings of the National Academy of Sciences, 1989
- Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast CancersScience, 1988