Inflammatory response to mucosal barrier injury after myeloablative therapy in allogeneic stem cell transplant recipients
- 1 August 2005
- journal article
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 36 (8) , 703-707
- https://doi.org/10.1038/sj.bmt.1705118
Abstract
We noted a significant increase of interleukin-8 (IL-8), LBP and CRP mirroring the pattern of mucosal barrier injury as measured by gut integrity (lactulose/rhamnose ratio), daily mucositis score (DMS) and serum citrulline concentrations of 32 haematopoietic stem cell transplant (HSCT) recipients following intensive myeloablative therapy. Concentrations of IL-8, LBP and CRP were already significantly elevated before the onset of fever or bacteraemia due to oral viridans streptococci (OVS) in the first week after transplant during profound neutropenia. These markers reached their peak when citrulline concentrations reached their nadir, the highest scores of DMS were attained and when there was significantly decreased gut integrity. This suggests that the degree of mucosal barrier injury rather than bacteraemia due to OVS determines the intensity of the inflammatory response.Keywords
This publication has 17 references indexed in Scilit:
- Monitoring myeloablative therapy‐induced small bowel toxicity by serum citrulline concentrationCancer, 2004
- Citrulline: a potentially simple quantitative marker of intestinal epithelial damage following myeloablative therapyBone Marrow Transplantation, 2004
- Functional modulation of enterocytes by gram-positive and gram-negative microorganismsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2004
- Measuring mucosal damage induced by cytotoxic therapySupportive Care in Cancer, 2004
- Role of curcumin and the inhibition of NF-κB in the onset of chemotherapy-induced mucosal barrier injuryLeukemia, 2003
- Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantationThe Pediatric Infectious Disease Journal, 2003
- Chemotherapy for cancer causes apoptosis that precedes hypoplasia in crypts of the small intestine in humansGut, 2000
- Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overviewBone Marrow Transplantation, 2000
- The impact of mucositis on ?-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignanciesCancer, 1998
- Bacteremia Due to Oral Viridans Streptococci in Neutropenic Patients with Cancer: Cytostatics Are a More Important Risk Factor than Antibacterial ProphylaxisClinical Infectious Diseases, 1995