Effects of Cardiopulmonary Bypass on the Phagocytic and Bactericidal Capacities of Polymorphonuclear Leukocytes

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Abstract
Studies on phagocytosis, intracellular digestion, and bactericidal capacity of polymorphonuclear leukocytes from patients undergoing cardiac surgery requiring a pump oxygenator reveal no significant abnormalities in these separate and distinct events. Furthermore, these cells reveal no differences from normal polymorphonuclear leukocytes in the morphological changes following phagocytosis. Polymorphonuclear leukocytes from heparinized fresh blood used for transfusions also demonstrated normal function. It is doubtful if impaired function of polymorphonuclear leukocytes from these patients contributes significantly to their apparently increased susceptibility to bacterial infection.

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